Searchable abstracts of presentations at key conferences in endocrinology

ea0086oc3.2 | Reproductive and Neuroendocrinology | SFEBES2022

BRF1-mediated paracrine signalling from pituitary stem cells is required for terminal differentiation of pituitary committed progenitors

Willis Thea L , Manshaei Saba , Reen Virinder , Pallikonda Husayn , Birch Jodie , Yianni Val , Lodge Emily J , Withers Dominic , Gil Jesus , Martinez-Barbera Juan Pedro , Andoniadou Cynthia L

The pituitary gland is a critical endocrine organ regulating multiple essential physiological processes including growth, reproduction, metabolism and the stress response. Hormone-producing pituitary cell lineages are derived from a population of embryonic precursors expressing the transcription factor SOX2. These cells maintain multipotency into early postnatal life, acting as the resident population of pituitary stem cells (PSCs) and contributing to all the endocrine cell li...